Enzyme-targeting drugs to be used in diabetes?

A research breakthrough could lead to a new class of drugs for diabetes, according to scientists, which could be welcome news to those looking to find a care home.

Investigators have discovered a new mechanism that turns up glucose production in the liver when blood sugar levels decrease, according to a study published in journal Cell.

This uncovered the central role for a group of enzymes known as histone deacetylases (HDACs), which are the target of new cancer drugs.

Reuben J Shaw, of Howard Hughes Medical Institute, said: "Drugs that specifically inhibit HDACs involved in gluconeogenesis may be very useful for the treatment of diabetes and metabolic syndrome."

In other news, using an 'artificial pancreas' could improve the control of diabetes at night, according to two trials published on bmj.com.

It was found that overnight blood glucose control could be improved by utilising a close loop insulin delivery system, which reduces the risk of nocturnal hypoglycaemia.

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