Three Sussex cyclists are raising money for the Motor Neurone Disease Association, according to the Sussex Express.
The cyclists will be riding the 350 miles from Land's End to their home town of Newick next month.
The Three Men on Bikes, comprising 24-year-old Brian Shears, John Coplestone, 61, and Brian Higgins, 63, decided to raise money for the charity after their friend Keith Shears was diagnosed with the disease.
Mr Coplestone told the newspaper: "We grew up together cycling and had great days on the London to Brighton ride. So it seemed appropriate to take up a challenge that has a direct link to Keith while also creating general awareness of the condition."
The trio will set off on May 13th and hope to reach Newick by the 21st to be in time for a fundraising day in the town organised by Motor Neurone Disease Association.
"We've been training since mid-winter and know it will be hard in places for people of advancing years. But the overnight stops may include the odd visit to a pub and that's another opportunity to put cash in the coffers," Mr Coplestone added.
The disease affects around seven in every 100,000 inhabitants of the UK.