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Compound identified to stop clots without bleeding risk

Compound identified to stop clots without bleeding risk
24th July 2012

Researchers have identified a compound capable of stopping the formation of blood clots without causing bleeding.

A study at Duke University Medical Centre found that PAMAM G-3, which mops up debris of damaged cells in the bloodstream, is capable of preventing the process that leads to blood clots, without activating those factors that cause bleeding.

Dr Bruce A Sullenger, senior author of the study, commented: "In the thrombosis (clotting) space, the holy grail has been to make something anti-thrombotic that doesn't significantly increase your chance of haemorrhage or bleeding.

"We think this is a promising example of a type of compound that could do that."

Researchers hope that the compound can be clinically developed to improve the safety and outcome of treating patients with thrombotic disease.

The discovery also has important ramifications for treating people that have experienced a stroke.

Many existing medications and procedures also struggle to find a balance between stopping clots and causing further bleeding.

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