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Brain receptor research could lead to new Alzheimer's treatment

Brain receptor research could lead to new Alzheimer's treatment
11th October 2011

New brain receptor research could offer promising new drug targets for Alzheimer's and other neurological diseases.

Researchers at the University of Buffalo have discovered a critical piece of receptor that fuels the brain.

"If we could find a drug that attaches itself to this site and locks together NMDA receptor subunits, that would be huge for fighting disability from Stroke and Alzheimer's," stated Gabriela K. Popescu, associate professor of Biochemistry and senior author of the study.

Receptors govern how brain cells communicate. The understanding of this process is vital for combating neurological diseases, such as stroke.

Research has proven that deprivation of estrogen can greatly reduce the number of brain receptors and help to prevent stroke.

After long periods of estrogen deprivation, an enzyme called carboxyl terminus of Hsc70 (CHIP) interacting protein increased binding estrogen receptor alpha, one of the major brain receptors for neuprotection.

While CHIP levels remained unchanged, the increased binding caused half of the receptors to be degraded.

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