Overexpression of proteins cause chemotherapy resistance
Overexpression of the proteins 14-3-3 may be one of the causes of chemotherapy resistance, according to a new study.
Dr Julian Ceron and Dr Simo Schwartz claim that the germ line functions of par-5, one of the two 14-3-3 proteins, can make tumours resistant to treatment.
Par-5 controls DNA damage response in the body and prevents the accumulation of no-cause DNA damage and genome instability.
Its ability to repair the damage caused by chemotherapy goes into overdrive when overexpressed and protects tumours.
The discovery, while based on a worm model, has implications for clinical practice if confirmed and could lead to new treatments that prevent overexpression of proteins.
One such treatment may be CDK-1 phosphorylation, which is known to stop cell cycles and could block par-5.
The discovery follows the release of findings from a study at the University of Hull, which claimed that the prevalence of a certain family of proteins could be used as a biomarker to predict chemotherapy resistance in breast cancer patients.
Find the nearest Barchester care home.
Find your nearest Barchester care home
With over 200 care homes in the UK, there's always a Barchester care home near you.