Attempts to identify genes that contribute to a susceptibility to complex neuropsychiatric disorders have not been very successful using conventional genetic approaches. According to researchers, several problems with this approach have revealed themselves, including carriers of genes being unable to be identified in the absence of symptoms and the heterogeneity of neuropsychiatric disorders. Scientists believe that identifying neurobiological or neurobehavioural characteristics associated with complex neuropsychiatric disorders, or endophenotypes, that may be closely linked to gene expression is a promising new research target. Endophenotype plays an important role to bridge the gap between microscopic level and macroscopic level of neuropsychiatric disorders. Identifying endophenotype, along with the advanced genetic analysis such genomewise association studies, will be crucial to the identification of genes that contribute to mental health issues. It was previously believed that information processing abnormalities and brain-related circuit dysfunction may be key to finding the genetic basis of mental illnesses, such as depression and schizophrenia. Read about support and personalised care at Barchester care homes for anyone with mental health concerns.