Gene is 'master switch' for obesity

Gene is 'master switch' for obesity

A gene associated with type 2 diabetes and cholesterol levels is a master regulator affecting obesity, according to research, which could leave patients in need of assisted living.

Research led by King's College London and the University of Oxford found that the KLF14 gene was associated with the expression levels of multiple distant genes found in fat tissue, essentially acting as a 'master switch' for obesity.

Authors of the study, published in journal Nature Genetics, revealed the regulatory gene to be a possible target for future treatments for metabolic illnesses such as heart disease, obesity and diabetes - affecting many people using home care.

Study leader Professor Tim Spector, of King's College, said: "This has great therapeutic potential particularly as by studying large detailed populations such as the twins we hope to find more of these regulators."

In other news, research conducted at Massachusetts General Hospital has found that mildly obese amyotrophic lateral sclerosis (ALS) patients lived longer than those of a normal weight, indicating that obesity could actually prove positive in this instance.

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